Automatic memory management in .NET makes development a lot easier; however, it’s still easy to introduce memory leaks into your application. For example, in a complex application, it’s easy to forget to unregister event handlers, and these are notorious for holding on to objects which you don’t need to keep in memory any more. This typically leads to an increase in memory usage which, if it remains unchecked and unresolved, can lead to your application exhibiting poor performance, or even running out of memory and crashing. This is where a memory profiler becomes necessary.

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P.S. Of course you can profile memory if you have ANTS profiles. This is the best profiling tool out there